People who look up NAD+ usually find two things side by side: IV infusions and capsules. This page describes what each one is. It does not rank them by result, because human outcome evidence for NAD+ IV therapy remains limited (Alangari et al., Frontiers in Aging, 2026), and we have not reviewed the evidence for any supplement.
What NAD+ is
NAD+, short for nicotinamide adenine dinucleotide, is a coenzyme found in every cell in your body. It is used in the reactions that turn nutrients into energy and by the proteins that repair DNA. Levels are known to fall with age. Whether that is why a given person feels foggy or tired has not been established, and an NAD+ infusion has not been shown to change it.
What an NAD+ IV is
The NAD+ Drip is $249 for 250mg of NAD+ in one liter of IV fluid with electrolytes, and the 500mg tier is $449. NAD+ IV therapy puts the coenzyme directly into your bloodstream, so the whole 250mg or 500mg is delivered when the infusion is completed. That is a statement about the route, not about what the dose does once it arrives.
It takes 2 to 4 hours because NAD+ has to be infused slowly on purpose: too fast and it can cause flushing, chest tightness, nausea or cramping, so the nurse starts slow and adjusts the rate to how you feel. A licensed nurse stays for the whole infusion.
What an NAD+ supplement is
A supplement is taken by mouth and has to be absorbed through the gut before it reaches your bloodstream. Some products sold for NAD+ contain NAD+ itself and others contain a precursor, a molecule the body can use to make NAD+; the label says which. We do not sell supplements, and we make no comparison of results between any supplement and our drip.
What the evidence does and does not show
In an animal study, raising NAD+ levels restored mitochondrial function in old mice (Gomes et al., Cell, 2013). These animal findings do not establish benefits from NAD+ IV therapy in people. Human outcome evidence for NAD+ IV therapy remains limited (Alangari et al., Frontiers in Aging, 2026). So we describe the amount delivered and not a result.
The practical differences
- Route. The IV delivers the whole dose into your bloodstream when the infusion is completed; a supplement depends on absorption through the gut.
- Time. An NAD+ IV takes 2 to 4 hours with a nurse in the room; a supplement takes a moment.
- Cost. Our NAD+ Drip is $249 a visit for 250mg; a supplement is priced by its seller.
- Review. Before an NAD+ IV a Nurse Practitioner reviews your intake. A supplement is your own choice; tell whoever prescribes your medications that you take it.
Who books an NAD+ IV from us
People in a demanding work stretch, people over 40 who have read about it, athletes curious about it, and people who had one somewhere else and want it at home. Those are reasons people give us; none of them is a result we have measured, and we do not promise one. If you have never had NAD+ by IV, the Nurse Practitioner will usually suggest the 250mg dose first.
Read this before you book if any of these apply
- Anyone 17 or younger. No exceptions, and a parent's consent does not change it.
- Pregnancy. Possible, but your obstetric provider signs off on elective IV hydration before the visit, so tell us before you book.
- Heart failure, significant heart or valve disease, kidney disease or dialysis. A bag of fluid is a real volume load and the right answer may be less, or none. Tell us before you book.
- Anyone 60 or older. IV fluid volume is capped at one liter every two weeks with no extra-fluid add-ons, so mention your age range when you book.
- Anyone taking a water pill, lithium, an ACE inhibitor or ARB, metformin, an SGLT2 medication or a blood thinner. All of these change what is safe when you are dehydrated. Bring the list.
- Anyone on chemotherapy, steroids or medication that suppresses the immune system. Any fever needs urgent medical review, not a drip.
One addition for this drip: we do not treat alcohol or drug withdrawal; shaking, sweating, a racing heart or confusion after stopping drinking is medical care, not a drip. Get medical care today; a seizure, confusion or seeing things that are not there means call 911.
Chest tightness during NAD+ is a known rate effect: tell the nurse, who slows or stops the drip. Chest pain that continues once it is stopped, pain spreading to the arm or jaw, trouble breathing, or swelling of the lips or throat means call 911. An IV is elective wellness care and we are not a substitute for emergency care.
How a visit works
You book a time and a licensed nurse comes to your home, hotel or rental. Every visit includes a Good Faith Exam with a Nurse Practitioner: on-site when she administers your IV, or by brief video check-in beforehand when a Registered Nurse does. It is a screen before treatment, not a diagnosis. Plan for 2 to 4 hours, and the long end or longer at 500mg. The NAD+ Drip is $249 flat for 250mg. Travel is included across most of our service area. If your address is farther out, the exact amount is shown before you pay. How it works walks through each step, and the NAD+ explainer covers the molecule in more depth.
A&M IV Co. is a Nurse Practitioner-owned mobile IV practice based in Brentwood, serving Nashville and Middle Tennessee.